PIM Kinase Inhibitor VIII, R8-T198wt The human p27Kip1 C-terminus PIM-1 phosphorylation site- (Thr198) containing sequence is synthesized with an N-terminal Arg octamer/R8-containing sequence to facilitate its use as a cell-permeable, substrate-competitive PIM-1 inhibitor. Reported to completely prevents human prostate carcinoma DU145-derived tumor expansion for up to 17 days (0.5 µmol/animal on days 0 & 5; intratumoral injection) in mice in vivo when combined with a single Taxol (Cat. No. 580555) dosage on day zero (60 mg/kg; i.p.). Studies using FITC-conjugated R8-T198wt demonstrate that R8-T198wt-induced cell cycle arrest and apoptosis in PIM-1-expressing DU145 cells are direct consequences of inhibition of PIM-1-mediated p27Kip1 Thr198 and Bad Ser112 phosphorylation, respectively. 产品信息 Peptide Sequence H-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr-OH Form White solid Formulation Supplied as a trifluoroacetate salt Molar mass 2820.4 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO or H2O Chemical formula C111H211N59O26S1 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Regulatory Review