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Nodularin
A potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A)
Product Overview
Product Name: Nodularin
Alternate Name/Synonyms: Cyclo[3S-amino-9S-methoxy-2S,6E,8S-trimethyl-10-phenyl-4,6- decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)- 3-methyl-D-β-aspartyl-L-arginyl]
Description: Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. It inhibits PP2B only at higher concentrations ( IC₅₀ = 1.8 µM).
Peptide Sequence: N/A
Appearance: Liquid
Formulation: In Ethanol
CAS Number: 118399-22-7
Molecular Formula: C₄₁H₆₀N₈O₁₀
Molecular Weight: 824.96
Purity: ≥95%
Solubility:N/A
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC=C1C(=O)NC(C(C(=O)NC(C(=O)NC(C(C(=O)NC(CCC(=O)N1C)C(=O)O)C)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C)CCCN=C(N)N)C)C(=O)O
InChi: InChI=1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8+
InChi Key: IXBQSRWSVIBXNC-ANPQUZCZSA-N
PubChem CID: 6437077
MDL Number: MFCD16659855
USAGE: For Research Use Only! Not For Use in Humans. |