SIRT2 Inhibitor, B2 A potent SIRT2 inhibitor Product Overview Product Name: SIRT2 Inhibitor, B2 Alternate Name/Synonyms: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ Description: Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. Peptide Sequence: N/A Appearance: Yellow solid Formulation: N/A CAS Number: 115687-05-3 Molecular Formula: C₂₀H₁₇ClN₄O₃ Molecular Weight: 396.83 Purity: ≥95% Solubility:DMSO (>5 mg/ml) Storage Temp.: -20°C Shipping Conditions: gel pack Handling: Protect from air and light SMILES: C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl InChi: InChI=1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2 InChi Key: KLNPVNZJCWIQSK-UHFFFAOYSA-N PubChem CID: 3953303 MDL Number: MFCD02039810 USAGE: For Research Use Only! Not For Use in Humans.
