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Bromodomain Inhibitor, (+)-JQ1
A potent and highly specific BET inhibitor
Product Overview
Product Name: Bromodomain Inhibitor, (+)-JQ1
Alternate Name/Synonyms: t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Description: Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1268524-70-4
Molecular Formula: C₂₃H₂₅ClN₄O₂S
Molecular Weight: 456.99
Purity: ≥98% by HPLC
Solubility:DMSO (10 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChi Key: DNVXATUJJDPFDM-KRWDZBQOSA-N
PubChem CID: 46907787
MDL Number: MFCD19443648
USAGE: For Research Use Only! Not For Use in Humans. |