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Chelerythrine chloride
A selective protein kinase C (PKC) inhibitor
Product Overview
Product Name: Chelerythrine chloride
Alternate Name/Synonyms: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Description: Cell-permeable. A selective protein kinase C (PKC) inhibitor (IC₅₀ =0.66 µM). Chelerythrine is at least 100-fold more selective for PKCs than for other kinases. It induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3. In addition, Chelerythrine treated cells underwent apoptosis, with features that suggest involvement of the mitochondrial pathway, and through a mechanism that involves inhibition of the anti-apoptotic inhibitor BclXL.
Peptide Sequence: N/A
Appearance: Yellow to orange solid
Formulation: N/A
CAS Number: 3895-92-9
Molecular Formula: C₂₁H₁₈NO₄Cl
Molecular Weight: 383.82
Purity: ≥98% by HPLC
Solubility:DMSO (> 10 mg/ml) or H₂O (5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
InChi: InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
InChi Key: WEEFNMFMNMASJY-UHFFFAOYSA-M
PubChem CID: 72311
MDL Number: MFCD00060717
USAGE: For Research Use Only! Not For Use in Humans. |