NSC 66811 Potent MDM2 inhibitor Product Overview Product Name: NSC 66811 Alternate Name/Synonyms: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol Description: Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro. Peptide Sequence: N/A Appearance: White solid Formulation: N/A CAS Number: 6964-62-1 Molecular Formula: C₂₃H₂₀N₂O Molecular Weight: 340.42 Purity: ≥97% by HPLC Solubility:DMSO (~ 100 mM) Storage Temp.: -20°C Shipping Conditions: gel pack Handling: Protect from air and light SMILES: CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4 InChi: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3 InChi Key: WEENRMPCSWFMTE-UHFFFAOYSA-N PubChem CID: 248986 MDL Number: N/A USAGE: For Research Use Only! Not For Use in Humans.
