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ML130
A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor
Product Overview
Product Name: ML130
Alternate Name/Synonyms: 1-Tosyl-1H-benzo[d]imidazol-2-amine; Nodinitib-1
Description: Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC₅₀ = 0.56±0.04 µM). Displays high selectivity (>36-fold) over MDP-stimulated signaling in reporter cell lines containing both endogenous and overexpressed NOD2 proteins or TNF-⍺-induced NF-kB activation.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 799264-47-4
Molecular Formula: C₁₄H₁₃N₃O₂S
Molecular Weight: 287.34
Purity: ≥97% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N
InChi: InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChi Key: SRFABRWQVPCPRG-UHFFFAOYSA-N
PubChem CID: 1088438
MDL Number: MFCD04322367
USAGE: For Research Use Only! Not For Use in Humans. |