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GW501516
A selective agonist for PPARδ
Product Overview
Product Name: GW501516
Alternate Name/Synonyms: (2-Methyl-4-(((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid
Description: A selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 317318-70-0
Molecular Formula: C₂₁H₁₈F₃NO₃S₂
Molecular Weight: 453.5
Purity: ≥98% by HPLC
Solubility:DMSO (50 mg/ml) or EtOH (12 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O
InChi: InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
InChi Key: YDBLKRPLXZNVNB-UHFFFAOYSA-N
PubChem CID: 9803963
MDL Number: MFCD09033000
USAGE: For Research Use Only! Not For Use in Humans. |