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Emetine dihydrochloride
A protein synthesis inhibitor
Product Overview
Product Name: Emetine dihydrochloride
Alternate Name/Synonyms: 2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
Description: A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 316-42-7
Molecular Formula: C₂₉H₄₀N₂O₄·2HCl
Molecular Weight: 553.56
Purity: ≥98% by titration
Solubility:Water (~ 100 mg/ml)
Storage Temp.: +4°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.Cl.Cl
InChi: InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
InChi Key: JROGBPMEKVAPEH-GXGBFOEMSA-N
PubChem CID: 3068143
MDL Number: MFCD00135589
USAGE: For Research Use Only! Not For Use in Humans. |