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StemRegenin 1, Hydrochloride
A promoter of self-renewal of hematopoietic stem cells (HSCs)
Product Overview
Product Name: StemRegenin 1
Alternate Name/Synonyms: 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol hydrochloride; SR1
Description: A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 1227633-49-9
Molecular Formula: C₂₄H₂₃N₅OS.HCl
Molecular Weight: 466
Purity: ≥98% by HPLC
Solubility:DMSO (~ 10 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |