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Olaparib
A highly potent and selective PARP-inhibitor
Product Overview
Product Name: Olaparib
Alternate Name/Synonyms: 4-(3-(4-(cycloprppanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one; ADZ-2281; KU-59436
Description: Cell-permeable. A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast cancer cells.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 763113-22-0
Molecular Formula: C₂₄H₂₃FN₄O₃
Molecular Weight: 434.46
Purity: ≥98% by HPLC
Solubility: DMSO (~33 mg/ml) or EtOH (~ 1.7 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
InChi: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChi Key: FDLYAMZZIXQODN-UHFFFAOYSA-N
PubChem CID: 23725625
MDL Number: MFCD13185161
USAGE: For Research Use Only! Not For Use in Humans. |