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Bisindolylmaleimide I
A Potent and ATP-competitive protein kinase C (PKC) inhibitor
Product Overview
Product Name: Bisindolylmaleimide I
Alternate Name/Synonyms: 3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide; GF 109203X; Gö 6850; BIM I
Description: Cell-permeable. A Potent and ATP-competitive protein kinase C (PKC) inhibitor (Ki = 10 nM). Also acts as a potent Glycogen synthase kinase-3 (GSK-3) inhibitor.
Peptide Sequence: N/A
Appearance: Orange solid
Formulation: N/A
CAS Number: 133052-90-1
Molecular Formula: C₂₅H₂₄N₄O₂
Molecular Weight: 412.49
Purity: ≥98% by NMR
Solubility:DMSO (~ 10 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChi: CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
InChi Key: QMGUOJYZJKLOLH-UHFFFAOYSA-N
PubChem CID: 2396
MDL Number: MFCD00236428
USAGE: For Research Use Only! Not For Use in Humans. |