|
NSC 23766
A potent Rac1 inhibitor
Product Overview
Product Name: NSC 23766
Alternate Name/Synonyms: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Description: A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam 1 (IC₅₀ = 50 μM) without affecting the closely related GTPases, Cdc42, and RhoA activation. NSC 23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, etc.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 733767-34-5
Molecular Formula: C₂₄H₃₅N₇.3HCl
Molecular Weight: 530.97
Purity: ≥98% by HPLC
Solubility: Water (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C.Cl.Cl.Cl
InChi: InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
InChi Key: CPUHORIUXPQCHW-UHFFFAOYSA-N
PubChem CID: 16759159
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |