|
SU 6668
A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases
Product Overview
Product Name: SU 6668
Alternate Name/Synonyms: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Description: Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.
Peptide Sequence: N/A
Appearance: Orange red solid
Formulation: N/A
CAS Number: 252916-29-3
Molecular Formula: C₁₈H₁₈N₂O₃
Molecular Weight: 310.35
Purity: ≥98%
Solubility:DMSO (~100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light
SMILES: CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O
InChi: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9+
InChi Key: NHFDRBXTEDBWCZ-NTEUORMPSA-N
PubChem CID: 5995546
MDL Number: MFCD00149792
USAGE: For Research Use Only! Not For Use in Humans. |