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PP1
A potent Src-selective tyrosine kinase (TK) inhibitor.
Product Overview
Product Name: PP1
Alternate Name/Synonyms: 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Description: Cell-permeable. A potent Src-selective tyrosine kinase (TK) inhibitor. Inhibits p56lck and p59fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also inhibits Kit and Bcr-Abl tyrosine kinases.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 172889-26-8
Molecular Formula: C₁₆H₁₉N₅
Molecular Weight: 281.36
Purity: ≥98% by TLC
Solubility:DMSO (25 mg/ml) or Ethanol (10 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C
InChi: InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChi Key: ZVPDNRVYHLRXLX-UHFFFAOYSA-N
PubChem CID: 1400
MDL Number: MFCD01076570
USAGE: For Research Use Only! Not For Use in Humans. |