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PYR-41
An irreversible ubiquitin-activating enzyme (E1) inhibitor
Product Overview
Product Name: PYR-41
Alternate Name/Synonyms: 4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Description: Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Peptide Sequence: N/A
Appearance: Brown solid
Formulation: N/A
CAS Number: 418805-02-4
Molecular Formula: C₁₇H₁₃N₃O₇
Molecular Weight: 371.3
Purity: ≥98% by TLC
Solubility:DMSO (~25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChi Key: ARGIPZKQJGFSGQ-LCYFTJDESA-N
PubChem CID: 5335621
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |