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Piperlongumine
An anticancer agent
Product Overview
Product Name: Piperlongumine
Alternate Name/Synonyms: (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Description: A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 20069-09-4
Molecular Formula: C₁₇H₁₉NO₅
Molecular Weight: 317.34
Purity: ≥97%
Solubility:DMSO (~ 25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
InChi: InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
InChi Key: VABYUUZNAVQNPG-BQYQJAHWSA-N
PubChem CID: 637858
MDL Number: MFCD00075706
USAGE: For Research Use Only! Not For Use in Humans. |