|
FK-866
A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)
Product Overview
Product Name: FK-866
Alternate Name/Synonyms: N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Description: Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC₅₀ = ~1 nM).
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 658084-64-1
Molecular Formula: C₂₄H₂₉N₃O₂
Molecular Weight: 391.51
Purity: ≥98% by NMR
Solubility:DMSO (>30 mg/ml) and Ethanol
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChi: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChi Key: KPBNHDGDUADAGP-VAWYXSNFSA-N
PubChem CID: 6914657
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |