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JM6
A high-affinity inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase
Product Overview
Product Name: JM6
Alternate Name/Synonyms: 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole
Description: Cell-permeable. A slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated in neurodegeneration. JM6 reverses and prevents symptoms of neurodegenerative diseases like Alzheimer’s and Huntington’s in animal models. JM6 does not penetrate into the brain, but works by inhibiting KMO in the blood.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₃H₂₆N₄O₆S₂
Molecular Weight: 518.61
Purity: ≥98% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light
SMILES: COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=C(S2)CN3CCCCC3)C4=CC(=CC=C4)[N+](=O)[O-])OC
InChi: InChI=1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)
InChi Key: AOZLMMDVJOGGEQ-UHFFFAOYSA-N
PubChem CID: 24812126
MDL Number: MFCD22380618
USAGE: For Research Use Only! Not For Use in Humans. |