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GYY 4137
A slow-releasing, water-soluble hydrogen sulfide (H₂S) donor
Product Overview
Product Name: GYY 4137
Alternate Name/Synonyms: p-Methoxyphenyl)morpholino-phosphinodithioic acid
Description: A slow-releasing, water-soluble hydrogen sulfide (H₂S) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 106740-09-4
Molecular Formula: C₁₁H₁₅NO₂PS₂ · C₄H₁₀NO
Molecular Weight: 376.47
Purity: ≥95% by HPLC
Solubility:DMSO (15 mg/ml) or water (30 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: COC1=CC=C(C=C1)P(=S)(N2CCOCC2)[S-].C1COCC[NH2+]1
InChi: InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2
InChi Key: YZMHNNLDUWRZFW-UHFFFAOYSA-N
PubChem CID: 53393943
MDL Number: MFCD00079328
USAGE: For Research Use Only! Not For Use in Humans. |