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NSC 146109 hydrochloride
A p53 activator
Product Overview
Product Name: NSC 146109 hydrochloride
Alternate Name/Synonyms: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011
Description: Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 59474-01-0
Molecular Formula: C₁₇H₁₆N₂S.HCl
Molecular Weight: 316.85
Purity: ≥98% by HPLC
Solubility:DMSO (100 mM) or EtOH (10 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from moisture
SMILES: CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl
InChi: InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
InChi Key: VIBMUYOXJUCEMA-UHFFFAOYSA-N
PubChem CID: 16759161
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |