CRT Inhibitor, iCRT5

CRT Inhibitor, iCRT5
A β-catenin-responsive transcription (CRT) inhibitor
Product Overview
Product Name: CRT Inhibitor, iCRT5
Alternate Name/Synonyms: (Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
Description: Cell-permeable. A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC₅₀ of 18 nM. It acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₁₆H₁₇NO₅S₂
Molecular Weight: 367.44
Purity: ≥98% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.