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MIF-Antagonist, ISO-1
A migration inhibitory factor (MIF) antagonist
Product Overview
Product Name: MIF-Antagonist, ISO-1
Alternate Name/Synonyms: (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Description: Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 478336-92-4
Molecular Formula: C₁₂H₁₃NO₄
Molecular Weight: 235.24
Purity: ≥98% by HPLC
Solubility:DMSO (~25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1
InChi: InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3
InChi Key: CLVQGFPQFNASJH-UHFFFAOYSA-N
PubChem CID: 6098948
MDL Number: MFCD22376813
USAGE: For Research Use Only! Not For Use in Humans. |