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Nimbolide
An anticancer agent
Product Overview
Product Name: Nimbolide
Alternate Name/Synonyms: (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
Description: A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 25990-37-8
Molecular Formula: C₂₇H₃₀O₇
Molecular Weight: 466.52
Purity: ≥98% by TLC
Solubility:DMSO (~50 mM) or Ethanol (~ 8 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C
InChi: InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3
InChi Key: JZIQWNPPBKFOPT-UHFFFAOYSA-N
PubChem CID: 100017
MDL Number: MFCD01735386
USAGE: For Research Use Only! Not For Use in Humans. |