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GDC-0449
A Smoothened (Smo) antagonist
Product Overview
Product Name: GDC-0449
Alternate Name/Synonyms: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Description: A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 879085-55-9
Molecular Formula: C₁₉H₁₄Cl₂N₂O₃S
Molecular Weight: 421.3
Purity: ≥98% by HPLC
Solubility:DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
PubChem CID: 24776445
MDL Number: MFCD12407408
USAGE: For Research Use Only! Not For Use in Humans. |