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Necrostatin-5
A necroptosis inhibitor
Product Overview
Product Name: Necrostatin-5
Alternate Name/Synonyms: 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide; Nec-5
Description: Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 337349-54-9
Molecular Formula: C₁₉H₁₇N₃O₂S₂
Molecular Weight: 383.49
Purity: ≥98% by NMR
Solubility:DMSO (~10 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4
InChi: InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChi Key: VGONMECBFMCKBS-UHFFFAOYSA-N
PubChem CID: 1913406
MDL Number: MFCD01448275
USAGE: For Research Use Only! Not For Use in Humans. |