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Necrostatin-1
A necroptosis inhibitor
Product Overview
Product Name: Necrostatin-1
Alternate Name/Synonyms: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1
Description: Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC₅₀ = 180 nM).
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 4311-88-0
Molecular Formula: C₁₃H₁₃N₃OS
Molecular Weight: 259.33
Purity: ≥98% by TLC
Solubility:DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChi: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key: TXUWMXQFNYDOEZ-UHFFFAOYSA-N
PubChem CID: 2828334
MDL Number: MFCD00056916
USAGE: For Research Use Only! Not For Use in Humans. |