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5-Azacytidine
A DNA methyltransferase inhibitor
Product Overview
Product Name: 5-Azacytidine
Alternate Name/Synonyms: 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Ladakamycin
Description: A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes. Also recently shown to increase reprogramming efficiency of stem cells 10-fold.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 320-67-2
Molecular Formula: C₈H₁₂N₄O₅
Molecular Weight: 244.2
Purity: ≥98% by TLC
Solubility:AcOH: H₂O (1:1) (5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
InChi: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)
InChi Key: NMUSYJAQQFHJEW-UHFFFAOYSA-N
PubChem CID: 1805
MDL Number: MFCD00006539
USAGE: For Research Use Only! Not For Use in Humans. |