|
Niclosamide
A STAT3 signaling pathway inhibitor
Product Overview
Product Name: Niclosamide
Alternate Name/Synonyms: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Description: A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Peptide Sequence: N/A
Appearance: Off-white to pale yellow solid
Formulation: N/A
CAS Number: 50-65-7
Molecular Formula: C₁₃H₈Cl₂N₂O₄
Molecular Weight: 327.12
Purity: ≥98% by HPLC
Solubility:DMSO (10 mM) or Ethanol (25 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChi: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChi Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
PubChem CID: 4477
MDL Number: MFCD00057597
USAGE: For Research Use Only! Not For Use in Humans. |