GANT58 A Hedgehog (Hh) signaling pathway inhibitor Product Overview Product Name: GANT58 Alternate Name/Synonyms: 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503 Description: Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo. Peptide Sequence: N/A Appearance: Yellow solid Formulation: N/A CAS Number: 64048-12-0 Molecular Formula: C₂₄H₁₆N₄S Molecular Weight: 392.48 Purity: ≥98% by HPLC Solubility: DMSO (25 mM) or Ethanol (25 mM) Storage Temp.: -20°C Shipping Conditions: gel pack Handling: Protect from air and light SMILES: C1=CN=CC=C1C2=C(SC(=C2C3=CC=NC=C3)C4=CC=NC=C4)C5=CC=NC=C5 InChi: InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H InChi Key: USWLOKMMUTWFMD-UHFFFAOYSA-N PubChem CID: 253078 MDL Number: MFCD01103196 USAGE: For Research Use Only! Not For Use in Humans.