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WP1066
A JAK2 inhibitor
Product Overview
Product Name: WP1066
Alternate Name/Synonyms: (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Description: A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 857064-38-1
Molecular Formula: C₁₇H₁₄BrN₃O
Molecular Weight: 356.22
Purity: ≥97% by HPLC
Solubility:DMSO (10 mg/ml) and Ethanol (5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
InChi: InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChi Key: VFUAJMPDXIRPKO-LQELWAHVSA-N
PubChem CID: 11210478
MDL Number: MFCD12912450
USAGE: For Research Use Only! Not For Use in Humans. |