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Bay 61-3606 Hydrochloride
A Syk inhibitor
Product Overview
Product Name: Bay 61-3606 Hydrochloride
Alternate Name/Synonyms: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl
Description: Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 732983-37-8
Molecular Formula: C₂₀H₁₈N₆O₃.HCl
Molecular Weight: 426.86
Purity: ≥98% by HPLC
Solubility: H₂O (30 mg/ml) DMSO (2 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl
InChi: InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H
InChi Key: HLYFDKZWVIBYKL-UHFFFAOYSA-N
PubChem CID: 52949496
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |