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Marimastat
A broad spectrum MMP inhibitor
Product Overview
Product Name: Marimastat
Alternate Name/Synonyms: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide; BB-2516; TA-2516; Marimistat
Description: A broad spectrum matrix metalloprotease (MMP) inhibitor with IC₅₀ values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 154039-60-8
Molecular Formula: C₁₅H₂₉N₃O₅
Molecular Weight: 331.41
Purity: ≥98% by HPLC
Solubility:DMSO (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C
InChi: InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
InChi Key: OCSMOTCMPXTDND-OUAUKWLOSA-N
PubChem CID: 119031
MDL Number: MFCD00866242
USAGE: For Research Use Only! Not For Use in Humans. |