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5-Aza-2'-deoxycytidine
An epigenetic modifier
Product Overview
Product Name: 5-Aza-2'-deoxycytidine
Alternate Name/Synonyms: 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine
Description: An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 2353-33-5
Molecular Formula: C₈H₁₂N₄O₄
Molecular Weight: 228.08
Purity: ≥98% by HPLC
Solubility:DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
InChi: InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
InChi Key: XAUDJQYHKZQPEU-KVQBGUIXSA-N
PubChem CID: 451668
MDL Number: MFCD00043011
USAGE: For Research Use Only! Not For Use in Humans. |