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GW2580
A cFMS kinase inhibitor
Product Overview
Product Name: GW2580
Alternate Name/Synonyms: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Description: A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 870483-87-7
Molecular Formula: C₂₀H₂₂N₄O₃
Molecular Weight: 366.41
Purity: ≥99% by HPLC
Solubility:DMSO (40 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
InChi: InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
InChi Key: MYQAUKPBNJWPIE-UHFFFAOYSA-N
PubChem CID: 11617559
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |