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JK 184
A hedgehog(Hh) signaling pathway antagonist
Product Overview
Product Name: JK 184
Alternate Name/Synonyms: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-y l)-2-thiazolamine
Description: An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC₅₀ = 210 nM).
Peptide Sequence: N/A
Appearance: Beige solid
Formulation: N/A
CAS Number: 315703-52-7
Molecular Formula: C₁₉H₁₈N₄OS
Molecular Weight: 350.44
Purity: ≥98% by HPLC
Solubility:DMSO (100 mM) and Ethanol (25 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
InChi: InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
InChi Key: ROYXIPOUVGDTAO-UHFFFAOYSA-N
PubChem CID: 1069686
MDL Number: MFCD01044465
USAGE: For Research Use Only! Not For Use in Humans. |