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U0126
Product Overview
Product Name: U0126
Alternate Name/Synonyms: 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene
Description: Potent and selective non-competitive inhibitor of MAP kinase kinase(MEK). Inhibits MEK-1 and MEK-2 (IC₅₀ values of 0.07 and 0.06 µM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 109511-58-2
Molecular Formula: C₁₈H₁₆N₆S₂
Molecular Weight: 380.48
Purity: ≥98% by HPLC
Solubility:DMSO (>10 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
InChi: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChi Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
PubChem CID: 3006531
MDL Number: MFCD01861186
USAGE: For Research Use Only! Not For Use in Humans. |