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Canertinib (CI-1033, PD-183805)
Product Overview
Product Name: Canertinib (CI-1033, PD-183805)
Alternate Name/Synonyms: CI-1033, PD-183805, PD 183805
Description: Canertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.
Peptide Sequence: N/A
Appearance: Off-white to pale green solid
Formulation: N/A
CAS Number: 289499-45-2
Molecular Formula: C₂₄H₂₅ClFN₅O₃ . 2HCl
Molecular Weight: 558.86
Purity: ≥99%
Solubility:DMSO (100 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from air and moisture
SMILES: C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
InChi: InChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
InChi Key: JZZFDCXSFTVOJY-UHFFFAOYSA-N
PubChem CID: 156413
MDL Number: MFCD09954112
USAGE: For Research Use Only! Not For Use in Humans. |