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BIBW2992 (Tovok)
Product Overview
Product Name: BIBW2992 (Tovok)
Alternate Name/Synonyms: Tovok
Description: BIBW-2992 is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC₅₀ values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 439081-18-2
Molecular Formula: C₂₄H₂₅ClFN₅O₃
Molecular Weight: 485.94
Purity: ≥99%
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from air and moisture
SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
InChi: InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChi Key: ULXXDDBFHOBEHA-CWDCEQMOSA-N
PubChem CID: 10184653
MDL Number: MFCD12407405
USAGE: For Research Use Only! Not For Use in Humans. |