|
Erlotinib, Hydrochloride Salt
Product Overview
Product Name: Erlotinib, Hydrochloride Salt
Alternate Name/Synonyms: CP-358774, OSI-774
Description: Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 183319-69-9
Molecular Formula: C₂₂H₂₃N₃O₄.HCl
Molecular Weight: 429.9
Purity: ≥99% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from light and moisture
SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
InChi: InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChi Key: GTTBEUCJPZQMDZ-UHFFFAOYSA-N
PubChem CID: 176871
MDL Number: MFCD07781272
USAGE: For Research Use Only! Not For Use in Humans. |