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Bosutinib (SKI-606)
Product Overview
Product Name: Bosutinib (SKI-606)
Alternate Name/Synonyms: SKI-606
Description: Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent. It is used to treat patients with chronic myelogenous leukemia (CML) who demonstrate resistance to Imatinib or develop resistance during treatment.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 380843-75-4
Molecular Formula: C₂₆H₂₉Cl₂N₅O₃
Molecular Weight: 530.45
Purity: ≥99% by HPLC
Solubility:DMSO (30 mg/ml) or EtOH (10 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from light and moisture
SMILES: CN1CCN(CC1)CCCOC2=CC3=NC(=CC(=C3C=C2OC)NC4=CC(=C(C=C4Cl)Cl)OC)C#N
InChi: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-26-14-22-18(12-25(26)35-3)21(11-17(16-29)30-22)31-23-15-24(34-2)20(28)13-19(23)27/h11-15H,4-10H2,1-3H3,(H,30,31)
InChi Key: ALUXPRDJABOEAG-UHFFFAOYSA-N
PubChem CID: 46926609
MDL Number: MFCD07367846
USAGE: For Research Use Only! Not For Use in Humans. |