NVP-AUY922

产品编号：	10012698-10 查看说明书
产品名称：	NVP-AUY922 .0 订购此产品
供应商：	Cayman
规格：	10 mg
目录价：	3080
库存状态：	3周
CAS编号：	747412-49-3
应用范围：
种属来源：
相关信息：
NVP-AUY922 Cayman Chemical Item Number 10012698 Description Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-AUY922 is a Hsp90 inhibitor (IC50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro with GI50s averaging 9nM.1↗ In a human colon cancer xenograft model, 50 mg/kg NVP-AUY922 inhibits tumor growth by ~50% compared to vehicle controls.1↗ Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-AUY922 is retained in tumors in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-bearing mice.1↗ Synonyms VER 52296 Formal Name 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide CAS Number 747412-49-3 Molecular Formula C26H31N3O5 Formula Weight 465.5 Formulation A crystalline solid Purity ≥98% λmax 310 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES OC1=CC(O)=C(C(C)C)C=C1C2=C(C3=CC=C(CN4CCOCC4)C=C3)C(C(NCC)=O)=NO2 InCHI Code 1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32) InCHI Key NDAZATDQFDPQBD-UHFFFAOYSA-N
保存条件：	-20°C
说明书地址：	点击查看详细

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