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Rosiglitazone-d5 Maleate
Cayman Chemical Item Number 10011343
Description
Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor κ-B (NF-κB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone.
Molecular Formula C22H18D5N3O7S
Formula Weight 412.9
Purity ≥99% deuterated forms (d1-d5)
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES OC(=O)\C=C\C(=O)O.O=C1SC(Cc2ccc(OCCN(C)c3ccccn3)cc2)C(=O)N1
InCHI Code 1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-/i1D3,11D2;
InCHI Key SUFUKZSWUHZXAV-APTGLFPKSA-N |