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JWH 180
Cayman Chemical Item Number 9001205
(CAS 824959-87-7)
Description
JWH 180 is a potent synthetic cannabinoid (CB) that binds both the central CB1 receptor (Ki = 26 nM) and the peripheral CB2 receptor (Ki = 9.6 nM).1↗ The physiological and toxicological properties of JWH 180 have not been characterized. Compounds like JWH 180 have been detected in herbal blends sold as recreational drugs.2↗,3↗,4↗ This product is intended for research and forensic applications.
1 Huffman, J.W., Zengin, G., Wu, M., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorg Med Chem 13 89-112 (2005).
2 Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg Med (Tokyo) 13(3) 109-15 (2011).
3 Ernst, L., Schiebel, H.M., Theuring, C., et al. Identification and characterization of JWH-122 used as new ingredient in 'spice-like' herbal incenses. Forensic Sci Int 208(1-3) e31-5 (2011).
4 Uchiyama, N., Kikura-Hanajiri, R., Ogata, J., et al. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Sci Int 198 31-38 (2010).
Formal Name (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone
CAS Number 824959-87-7
Molecular Formula C25H25NO
Formula Weight 355.5
Formulation A crystalline solid
Purity ≥98%
λmax 223, 316 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES Copy O=C(C1=CC=C(CCC)C2=C1C=CC=C2)C3=CN(CCC)C4=C3C=CC=C4
InCHI Code Copy 1S/C25H25NO/c1-3-9-18-14-15-22(20-11-6-5-10-19(18)20)25(27)23-17-26(16-4-2)24-13-8-7-12-21(23)24/h5-8,10-15,17H,3-4,9,16H2,1-2H3
InCHI Key Copy BMOMWXXAVVSIRU-UHFFFAOYSA-N |