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WIN 54,461
Cayman Chemical Item Number 9001204
Description
WIN 54,461 is an aminoalikylindole which acts as a cannabinoid (CB) mimetic, displacing WIN 55212-2 from CB receptors on rat cerebellum membranes (IC50 = 515 nM).1↗ As it antagonizes the inhibition of electrically-induced contractions in isolated mouse vas deferens preparations by tetrahydrocannabinol or pravadoline, it may act as a receptor antagonist.1↗ The physiological effects of WIN 54,461 in vivo have not been examined. This product is intended for research and forensic applications.
1 Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J Med Chem 38 3094-3105 (1995).
Synonyms 6-Bromopravadoline
Formal Name [6-bromo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone
CAS Number 166599-63-9
Molecular Formula C23H25BrN2O3
Formula Weight 457.4
Formulation A crystalline solid
Purity ≥98%
λmax 226, 283, 319 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(C1=C(C)N(CCN2CCOCC2)C3=CC(Br)=CC=C31)C4=CC=C(OC)C=C4
InCHI Code 1S/C23H25BrN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
InCHI Key DUYGSAPQVOBOCS-UHFFFAOYSA-N |