|
JWH 424
Cayman Chemical Item Number 9001203
(CAS 1366068-04-3)
Description
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1↗ This cannabimimetic compound has frequently been found in herbal blends. 2↗,3↗,4↗ JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.
1 Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend 60 133-140 (2000).
2 Auwärter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J Mass Spectrom 44 832-837 (2009).
3 Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci Int 191 58-63 (2009).
4 Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol 27 61-66 (2009).
Formal Name (8-bromonaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone
CAS Number 1366068-04-3
Molecular Formula C24H22BrNO
Formula Weight 420.3
Formulation A solution in methanol
Purity ≥98%
λmax 224, 315 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES Copy O=C(C1=CN(CCCCC)C2=C1C=CC=C2)C3=C4C(C=CC=C4Br)=CC=C3
InCHI Code Copy 1S/C24H22BrNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
InCHI Key Copy QXZYVJRMQVOOEQ-UHFFFAOYSA-N |