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Norsufentanil-d3
Cayman Chemical Item Number 9001143
R 30451-d3 (CAS 1204688-16-3)
Norsufentanil-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of norsufentanil by GC- or LC-mass spectrometry. Sufentanil is a powerful synthetic opioid analgesic that is used in anesthesia and palliative care.1↗,2↗,3↗ Norsufentanil is a metabolite of sufentanil, produced by oxidative N-dealkylation in the liver by cytochrome P450 isoforms.4↗ The physiological and toxicological properties of this compound are unknown. This product is intended for forensic applications.
1 Bovill, J.G., Sebel, P.S., and Stanley, T.H. Opioid analgesics in anesthesia: With special reference to their use in cardiovascular anesthesia. Anesthesiology 61 731-755 (1984).
2 Hodgson, P.S., Neal, J.M., Pollock, J.E., et al. The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 88 797-809 (1999).
3 King, S., Forbes, K., Hanks, G.W., et al. A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impirment: A European Palliative Care Research Collaborative opioid guidelines project. Palliat Med 25(5) 525-552 (2011).
4 Tateishi, T., Krivoruk, Y., Ueng, Y., et al. Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesth Analg 82 167-172 (1996).
Synonyms R 30451-d3
Formal Name N-[4-(methoxy-d3-methyl)-4-piperidinyl]-N-phenyl-propanamide
CAS Number 1204688-16-3
Molecular Formula C16H21D3N2O2
Formula Weight 279.4
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d3)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES Copy O=C(CC)N(C1=CC=CC=C1)C2(COC([2H])([2H])[2H])CCNCC2
InCHI Code Copy 1S/C16H24N2O2/c1-3-15(19)18(14-7-5-4-6-8-14)16(13-20-2)9-11-17-12-10-16/h4-8,17H,3,9-13H2,1-2H3/i2D3
InCHI Key Copy ULOZGJWEIWAWML-BMSJAHLVSA-N |