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Norsufentanil
Cayman Chemical Item Number 9001142
R 30451 (CAS 61086-18-8)
Description
Sufentanil is a powerful synthetic opioid analgesic that is used in anesthesia and palliative care.1↗,2↗,3↗ Norsufentanil is a metabolite of sufentanil, produced by oxidative N-dealkylation in the liver by cytochrome P450 isoforms.4↗ The physiological and toxicological properties of this compound are unknown. This product is intended for forensic applications.
1 Bovill, J.G., Sebel, P.S., and Stanley, T.H. Opioid analgesics in anesthesia: With special reference to their use in cardiovascular anesthesia. Anesthesiology 61 731-755 (1984).
2 Hodgson, P.S., Neal, J.M., Pollock, J.E., et al. The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 88 797-809 (1999).
3 King, S., Forbes, K., Hanks, G.W., et al. A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impirment: A European Palliative Care Research Collaborative opioid guidelines project. Palliat Med 25(5) 525-552 (2011).
4 Tateishi, T., Krivoruk, Y., Ueng, Y., et al. Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesth Analg 82 167-172 (1996).
Synonyms R 30451
Formal Name N-[4-(methoxymethyl)-4-piperidinyl]-N-phenyl-propanamide
CAS Number 61086-18-8
Molecular Formula C16H24N2O2
Formula Weight 276.4
Formulation A solution in methanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES Copy COCC1(N(C2=CC=CC=C2)C(CC)=O)CCNCC1
InCHI Code Copy 1S/C16H24N2O2/c1-3-15(19)18(14-7-5-4-6-8-14)16(13-20-2)9-11-17-12-10-16/h4-8,17H,3,9-13H2,1-2H3
InCHI Key Copy ULOZGJWEIWAWML-UHFFFAOYSA-N |