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ABH
Cayman Chemical Item Number 10006862
Description
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. ABH is a slow-binding competitive inhibitor of human arginase II with Ki values of 0.25 µM and 8.5 nM at pH 7.5 and 9.5, respectively.1↗ ABH enhances both male and female sexual arousal responses in rabbits, an effect which may be due to increased NO bioavailability resulting from arginase inhibition.2↗ Inhibition of arginase is therefore a potential therapeutic target for the treatment of sexual arousal disorders.
Synonyms Amino-2-Borono-6-Hexanoic Acid
Formal Name 6-borono-L-norleucine
CAS Number 222638-65-5
Molecular Formula C6H14BNO4
Formula Weight 175.0
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES OB(O)CCCC[C@H](C(O)=O)N
InCHI Code 1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)
InCHI Key HFKKMXCOJQIYAH-UHFFFAOYSA-N |