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trans-3,4’,5-Trimethoxy-stilbene
Description
Analog of resveratrol. Displays powerful antiangiogenic activity. Inhibits endothelial cell proliferation, sprouting, collagen gel invasion and morphogenesis; ID50=0.3-3µM. Induces microtubule disassembly and tubulin depolymerization. Inhibits antigen-induced release of TNF-α in RBL-2H3 cells. Acts as potent antagonist of AHR.
Specifications
Cas No. 22255-22-7
Product ID T7134
Product Name trans-3,4’,5-Trimethoxy-stilbene
Formula Wt. 270.32
Solubility Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide.
References Antitumor activity of 3,5,4’-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice: M.H. Pan, et al.; Mol. Carcinog. 47, 184 (2008), Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4’-trimethoxystilbene: M. Belleri, et al.; Mol. Pharmacol. 67, 1451 (2005),
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